Robert Eoff, Ph.D., has received a $1.2 million grant from the National Science Foundation to continue his work at the University of Arkansas for Medical Sciences on DNA damage, cell replication and its implications for diseases like dementia, ALS and cancer.
Eoff is an associate professor in the Department of Biochemistry and Molecular Biology in the UAMS College of Medicine and a member of UAMS' Winthrop P. Rockefeller Cancer Institute.
Julie Gunderson, Ph.D., assistant professor of physics at Hendrix College in Conway, is collaborating with Eoff on the project.
The four-year grant will also support graduate student training at UAMS and undergraduate trainees at Hendrix.
For this grant, Eoff's team will study the role of a special enzyme called Rev1 in copying G-quadruplexes (G4) sequences. Rev1 is a DNA polymerase — an enzyme that catalyzes the synthesis of new strands of DNA.